The timely diagnosis of potentially lethal melanomas requires vigilance and attention to the basic principles taught in medical school: thoughtful history-taking followed by thorough examination.
Melanomas reflect the chaotic growth of malignant cells, which is why dermatoscopic chaos (asymmetry of structure and/or colour) and other clues become increasingly apparent as they grow.
The dermatoscopic algorithm Chaos and Clues relies on the chaotic behaviour of malignant tissue to produce both asymmetry (chaos) and clues to malignancy (Figure 2).
Diagnostic algorithms assist the clinician to triage lesions systematically and to identify those that require (excision) biopsy. An algorithm is also a useful structure on which to organise
The decision algorithm Chaos and Clues, like most published dermatoscopic decision algorithms for pigmented skin lesions, relies primarily on asymmetry to flag suspicion of malignancy.
While malignant tissue defies natural laws and grows chaotically there are some sites where that chaotic growth is restrained in the early growth of a tumour by architectural obstacles.